Background :
@EN Hydrofluoric acid(HF) is one of the strongest irritating, corrosive and poisonous inorganic acid. The HF burns are occuring with ever-increasing with ever-increasing frequency due to the wide use of this acid in industrial fields, such as
electronics and semiconductor industries.
@ES Objective :
@EN The purpose of this study is to quantiate the wound depths produced by varying concentrations of HF and to suggest the treatment gudelines.
@ES Methods :
@EN Various concentrations of HF (5%, 25%, 50%) were applied to two pairs of test sites on a guinea pig's back in a uniform fashion with cotton-tip applicators and then the histopathologic changes of guinea pig skin were observed.
@ES Results :
@EN 1. In the 5% applied group, intracellular edema was observed in the epidermis after 12hours. After 3days, epidermal cell necrosis was observed.
2. In the 25% HF applied group, intraepidermal vesicle was observed after 6hours. After 12hours, inflammatory cell infiltrations were observed in the upper drmis and then after 3days, dermal necrosis was observed.
3. In the 50% HF applied group, epidermal cell necrosis was observed focally after 3hours. After 6hours, liquefaction degeneration in the epidermis and inflammatory cell infiltrations in the upper dermis were observed.
@ES Conclusion :
@EN This study showed that a higher concentration of HF and a longer priod after HF exposure enhances the penetration of HF. For treatment, we suggest wet dressing with an alcohloic solution of a quarternary ammonium fora low concentration of HF
burn
and intralesional injection of calcium gluconate within 24 hour for a hign concentration of HF burn.
(Kor J Dermatol 1995;33(3) : 482~488)
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